2007 Conference Abstracts

Adler, B. (2007) The surface of Pasteurella multocida: genetics, structure and pathogenesis.  9th Australian Bacterial Pathogenesis Meeting, Lorne, Australia, 2007.

Adler, B., Al-Hasani, K., McCarl, V., Bottomley, S., Wilkie, I., and Boyce, J. (2007) High throughput approach to vaccine development in pasteurellosis.  From Molecules to Complex Systems, Joint NZMS/NZSBMB Conference, Wellington, New Zealand, 2007.

Al-Hasani, K., Navarro-Garcia, F., Sakellaris, H., Boyce, J.D. and Adler, B. (2007) SigA, the secreted autotransporter enterotoxin of Shigella flexneri 2a cleaves human a-fodrin.  9th Australian Bacterial Pathogenesis Meeting, Lorne, Australia, 2007.

Awad, M.M., Tan, J., Phumoonna, T., McEwan, A. and Rood, J.I.  (2007) Iron acquisition in Clostridium perfringens strain 13. 9th Australian Bacterial Pathogenesis Conference, Lorne, Victoria, 2007.

Bannam, T.L., Teng, W.L., Parsons, J.A., Bantwal, R., Devenish, R.J. and Rood, J.I. (2007) Deciphering a unique clostridial conjugation system. Functional Genomics of Gram Positive Microrganisms, Tirrenia, Italy, 2007.

Bantwal, R., Bannam, T.L. and Rood, J.I.  (2007) Role of tcpC, tcpG and tcpI in the conjugative transfer of pCW3.  9th Australian Bacterial Pathogenesis Conference, Lorne, Victoria, 2007.

Battad, J.M., Byres, E., Don Paul, C., Devenish, R.J., Rossjohn, J. and Prescott, M. (2007) The role of a conserved tyrosine in the chromophore configuration of the blue chromoprotein Rtms5.  32nd Annual Lorne Conference on Protein Structure and Function, Lorne, Victoria, 2007.

Boyce, J., Harper, M., Cox, A.D., St. Michael, F., Parnas, H., Wilkie, I., Blackall, P.J. and Adler, B. (2007) Decoration of P. multocida LPS by phosphocholine is important for virulence.  9th Australian Bacterial. Pathogenesis Meeting, Lorne, Australia, 2007.

Bulach, D., Adler, B., Coppel, R.L., Seemann, T. (2007) Auto-annotation of bacterial genomic sequences.  9th Australian Bacterial Pathogenesis Meeting, Lorne, Australia, 2007.

Carrillo-Cassas, E., Hernandez-Castro, R., Suarez-Guemes, F., Bulach, D., Adler, B. and de la Pena Moctezuma, A. (2007) Transcription of the Leptospira interrogans serovar Hardjo (Hardjoprajitno) wzx is downregulated in contrast to wzy.  5th Scientific Meeting of the International Leptospirosis Society, Quito, Ecuador, 2007.

Carter, G.P., Liras, D., Allen, D.L., Macklin, K., Howrah, P.M., O’Connor, J.R. and Rood, J.I.  (2007) The Cut response regulator activates the production of binary toxin in Clostridium difficile.  9th Australian Bacterial Pathogenesis Conference, Lorne, Victoria, 2007.

Cullinane, M., Gong, L., Lazar-Adler, N., Prescott, M., Boyce, J.D., Devenish, R.J. and Adler, B.  (2007) Stimulation of autophagy suppresses the intracellular survival of Burkholderia pseudomallei in mammalian cell lines.  5th World Melioidosis Congress, Khon Kaen, Thailand, 2007.

Cheng, L., Smith, D.J., Nagley, P. and Anderson, R.L. (2007) Heat shock proteins in neuronal cell survival: role of hsp72 in the resistance of neurone-like SH-SY5Y cells to apoptotic insults. 7th IBRO World Congress of Neuroscience, Melbourne, Victoria, 2007.

Cheng, L., Smith, D.J., Nagley, P. and Anderson, R.L. (2007) The role of Hsp72 in neuronal cell survival and the resistance of neurone-like SH-SY5Y cells to apoptotic insults.  The 2007 World Congress of Stress with the 3rd Cell Stress Society International Congress on Stress Responses in Biology and Medicine, Budapest, Hungary, 2007.

Cheung, J.K., McGowan, S., Awad, M.M., Katayama, S. and Rood, J.I.  (2007) Phosphorylation and concentration dependent activation of proa transcription by the Vir response regulator in Clostridium perfringens.  Functional Genomics of Gram Positive Microrganisms, Tirrenia, Italy, 2007.

Cheung, J.K., McGowan, S., Awad, M.M., Katayama, S. and Rood, J.I. (2007) Signal Transduction in the VirS/VirR System of Clostridium perfringens. Australian Society for Microbiology, Annual Scientific Meeting, Adelaide, South Australia, 2007.

Cheung, J.K., McGowan, S., Awad, M.M., Katayama, S. and Rood, J.I.  (2007) Activation of pfoA transcription by the VirR response regulator in Clostridium perfringens is phosphorylation and concentration dependent., 9th Australian Bacterial Pathogenesis Conference, Lorne, Victoria, 2007.

Crellin, P, Beddoe, T., Marland, Z., Zaker-Tabrizi, L., Byres, E., Scoble, J., Brammananth, R., Sallmann, G., Rossjohn, J., and Coppel, R. (2007) A drug discovery pipeline for high-throughput expression and structure determination of essential mycobacterial enzymes. Keystone Symposium: Tuberculosis, from lab research to Field Trials, Vancouver, Canada, 2007.

Cullinane, M., Gong, L., Lazar-Adler, N., Prescott, M., Boyce, J.D., Devenish, R.J. and Adler, B. (2007) Autophagy decreases the survival of Burkholderia pseudomallei in phagocytic cells but not in non-phagocytic cell lines. 9th Australian Bacterial. Pathogenesis Meeting, Lorne, Australia, 2007.

Davies, J.K. (2007) Gene regulation strategies in bacterial species with small genomes.  Annual Scientific Meeting of the Australian Society for Microbiology, Adelaide, South Australia, 2007.

D’Cruze, T., Adler, B., Prescott, M. and Devenish, R.J. (2007) Expression of Burkholderia pseudomallei proteins in yeast can affect vesicle trafficking and vacuolar morphology. 5th World Melioidosis Congress, Khon Kaen, Thailand, 2007.

D’Cruze, T., Adler, B., Prescott, M., and Devenish, R.J. (2007) Expression of Burkholderia pseudomallei proteins in yeast can affect vesicle trafficking and vacuolar morphology.  23rd International Conference on Yeast Genetics and Molecular Biology, Melbourne, Victoria, 2007. 

D’Cruze, T.M., Mijaljica, D., Adler, B., Prescott, M. and Devenish, R.J. (2007) Characterisation of candidate pathogen effector proteins of B. pseudomallei by expression screening in yeast.  32nd Annual Lorne Conference on Protein Structure and Function, Lorne, Victoria, 2007.

Harper, M., St. Michael, F., Boyce, J.D., Adler, B. and Cox, A.D. (2007) Structural and genetic analyses of LPS biosynthesis in diverse Pasteurella multocida serotypes.  9th Australian Bacterial Pathogenesis Meeting, Lorne, Australia,

Hatfaludi, T., Al-Hasani, K., Boyce, J. and Adler, B. (2007) Efflux pump protein from Pasteurella multocida: TolC.  9th Australian Bacterial Pathogenesis Meeting, Lorne, Australia, 2007.

Higgins, G.C., Beart, P.M. and Nagley, P. (2007) Reactive oxygen species cause neuronal apoptosis-like cell death in the absence of downstream caspase activity. 7th IBRO World Congress of Neuroscience, Melbourne, Victoria, 2007. 

Hoke, D. and Adler, B. (2007) LipL32 is an extracellular matrix-interacting protein of Leptospira interrogans.  9th Australian Bacterial Pathogenesis Meeting, Lorne, Australia, 2007.

Hughes, M.L., Poon, R., Adams, V., Sayeed, S., Saputo, J., Uzal, F.A., McClane, B.A. and Rood, J.I.  (2007) Epsilon toxin plasmids of Clostridium perfringens type D are conjugative.  9th Australian Bacterial Pathogenesis Conference, Lorne, Victoria, 2007.

Jenkin, G., Markovska, V., Smith, D., Wang, P., Mansell, A., Hertzog, P., Visvanathan, K., Stinear, T. and Davies, J.K.  (2007) The effects of mycolactone on Toll-like receptor signalling.  9th Australian Bacterial Pathogenesis Conference, Lorne, Victoria, 2007.

Kennan, R.M., Wong, W.C., Parker, D. and Rood, J.I. (2007) Isolation and characterisation of protease mutants of Dichelobacter nodosus, 9th Australian Bacterial Pathogenesis Conference, Lorne, Victoria, 2007.

Kennedy, C.L, Lyras, D., Daniel, L., Melton-Witt, J., Emmons, J.J., Smith, D., Tweten, R.K. and Rood, J.I.  (2007) Clostridium septicum a-toxin mutations have different effects in vitro and in vivo and greater activity against nucleated cells.  9th Australian Bacterial Pathogenesis Conference, Lorne, Victoria, 2007.

Keyburn, A.L., Sheedy, S.A., Ford, M.E., Vaz, P., Parker, D., Bannam, T.L., Boyce, J.D., Williamson, M.M., Rood, J.I. and Moore, R.J.  (2007) NetB, a novel Clostridium perfringens toxin that is an essential virulence factor for necrotic enteritis in chickens. 9th Australian Bacterial Pathogenesis Conference, Lorne, Victoria, 2007.

Khoo, C., Lo, M., Quinsey, N., Bulach, D.M. and Adler, B. (2007) Opening the Gateway – Our experience with cloning and expressing 260 recombinant bacterial proteins.  9th Australian Bacterial Pathogenesis Meeting, Lorne, Australia, 2007.

Lai, Z.W, Lew, R.A, Mu, F.T, Andrews, R.K. and Smith, A.I.  (2007) Identification of a Calmodulin-binding Domain within the Cytoplasmic tail of Angiotensin-Converting Enzyme 2 (ACE2).  32nd Annual Lorne Conference on Protein Structure and Function, Lorne, Victoria, 2007. 

Lazar-Adler, N., Govan, B., Harper, M., Adler, B. and Boyce, J.D. (2007) A Burkholderia pseudomallei sensor kinase mutant (BPSS0687) is attenuated in the BALB/c murine model of melioidosis.  5th World Melioidosis Congress, Khon Kaen, Thailand, 2007.

Lea-Smith, D., Pyke J., Tull, D., McConville,M., Coppel, R. and Crellin, P. (2007) Identification of the reductase that catalyzes mycolic motif biosynthesis in Corynebacterineae. Keystone Symposium: Tuberculosis, from lab research to Field Trials, Vancouver, Canada, 2007.

Levett, P., Adler, B., Hartskeerl, R. and Smythe, L. (2007) Recent taxonomoic changes in the genus Leptospira.  5th Scientific Meeting of the International Leptospirosis Society, Quito, Ecuador, 2007.

Lo, M., Cordwell, S.J. and Adler, B. (2007) Sifting through the MudPIT – comparative analysis of leptospiral outer membrane protein expression at the transcriptional and translational levels.  9th Australian  Bacterial Pathogenesis Meeting, Lorne, Australia, 2007.

Lo, M., Cordwell, S., Bulach, D. and Adler, B. (2007) Sifting through the MuDPIT: comparative transcriptional and translational analysis of leptospiral outer membrane protein expression in response to temperature.  5th Scientific Meeting of the International Leptospirosis Society, Quito, Ecuador, 2007.

Lyras, D., Sambol, S., Howarth, P.M., O’Connor, J.R., Carter, G.P., Johnson, S., Gerding, D.N. and Rood, J.I.  (2007) Construction and Analysis of Chromosomal Toxin Mutants of Clostridium difficile.  Australian Society for Microbiology, Annual Scientific Meeting, Adelaide, South Australia, 2007.

Lyras, D., Sambol, S., Howarth, P., O’Connor, J., Carter, G., Phumoonna, T., Johnson, S., Gerding, D. and Rood, J.I.  (2007) Genetic and functional analysis of the major toxin genes of Clostridium difficile.  9th Australian Bacterial Pathogenesis Conference, Lorne, Victoria, 2007.

Mercer, L.D., Kardashyan, L., Diwakarla, S., Nagley, P. and Beart, P.M. (2007) Recruitment of mitochondrial Signalling in apoptotic GABAergic striatal neurons.  7th IBRO World Congress of Neuroscience, Melbourne, Victoria, 2007.

Mijaljica, D., Prescott, M. and Devenish, R.J. (2007) Vacuolar turnover of the nucleus in yeast cells lacking ATG gene products: uncovering selectivity? 23rd International Conference on Yeast Genetics and Molecular Biology, Melbourne, Victoria, 2007. 

Murray, G., Coutts, S. and Adler, B. (2007) Leptospiral FlaA is required for translational but not rotational motility.  5th Scientific Meeting of the International Leptospirosis Society, Quito, Ecuador, 2007.

Murray, G., Ellis, K. and Adler, B. (2007) Leptospira interrogans requires a functional haem oxygenase to scavenge iron from haemoglobin.  9th Australian Bacterial Pathogenesis Meeting, Lorne, Australia, 2007.

Parsons, J.A, Bannam, T.L, Devenish, R.J. and Rood, J.I. (2007) Functional analysis of TcpA, the putative coupling protein of the conjugative plasmid pCW3 from C. perfringens. Australian Society for Microbiology, Annual Scientific Meeting, Adelaide, South Australia, 2007.

Parsons, J.A, Bannam, T.L, Devenish, R.J. and Rood, J.I.  (2007) Identification and characterization of TcpA, an FtsK/SpoIIIE homologue that is essential for transfer of the conjugative plasmid pCW3 in Clostridium perfringens.  9th Australian Bacterial Pathogenesis Conference, Lorne, Victoria, 2007.

Pettikikriarachchi, A., Gong, L., Perugini, M., Devenish, R.J. and Prescott, M. (2007) ‘Chromoprotein blues’ – recolouring a monomeric chromoprotein using random mutagenesis.  32nd Annual Lorne Conference on Protein Structure and Function, Lorne, Victoria, 2007.

Picardeau, M., Bulach, D., Zuerner, R., Bouchier, C., Zidane, N., Wilson, P., Creno, S., Kuczek, E., Bommezzadri, S., Davis, J., McGrath, A., Roche, D., Johnson, M., Boursaux-Eude, C., Seemann, T., Roy, Z., Coppel, R., Rood, J., Lamus, A., Davies, J., Meringue, C., and Adler, B. (2007) Whole-genome sequencing of the saprophyte L. biflexa and comparative genomics of pathogenic and saprophytic Leptospira species. 5th Scientific Meeting of the International Leptospirosis Society, Quito, Ecuador, 2007.

Picot, S.J., Hong, H., Leadlay P., Seemann, T., Porter, J.L., Men, A., Johnson, M., Wilson, P., Davies, J.K. and Stinear, T.P. (2007) Evolution of the plum virulence plasmid of Mycobacterium ulcerans.  9th Australian Bacterial Pathogenesis Conference, Lorne, Victoria, 2007.

Porter, C.J., Wong, W., Kennan, R.M., Parker, D., Buckle, A.M.,  McGowan, S.,  Law, R.H., Rood, J.I. and Whisstock, J.C.  (2007) A disulphide tethered loop confers elastase-like activity on Aprv2, an acidic protease secreted by Dichelobacter nodosus.  9th Australian Bacterial Pathogenesis Conference, Lorne, Victoria, 2007.

Rainczuk, K., Hamilton, C.W., Lyons-Schindler, S.H.V. and Davies, J.K. (2007) A cautionary tale regarding microarray experiments.  9th Australian Bacterial Pathogenesis Conference, Lorne Victoria, 2007.

Rodriguez, E., Alcaraz, L., Cullen, P., Bulach, D., Adler, B., Haake, D., and de la Pena Moctezuma, A. (2007) GspD, the type two secretion system (T2SS) secretin of Leptospira is expressed during infection.  5th Scientific Meeting of the International Leptospirosis Society, Quito, Ecuador, 2007.

Rood, J.I., Adams, V. and Lyras, D. (2007) The Role of Large Serine Recombinases in the Insertion and Excision of Mobile Antibiotic Resistance Elements from the Pathogenic Clostridia, Australian Society for Microbiology, Annual Scientific Meeting, Adelaide, South Australia, 2007.

Ryan, C., Turner, S., Martin, L, Zhang, H., Ng, S., Whisstock, J.C., Mechler, A. and Davies, J.K. (2007) Transcriptional regulation of the pilE gene of Neisseria gonorrhoeae.  9th Australian Bacterial Pathogenesis Conference, Lorne, Victoria, 2007.

Smith, A.I. (2007) Grant Writing Tips and Traps for young Players; NH&MRC, Sydney Complementary Medicine Forum, Sydney, New South Wales, 2007.

Smith, A.I. (2007) Proteins for Structural and Biological Studies, 8th Protein Expression Workshop, Melbourne, Victoria, 2007.

Smith, A.I., Warner, F.J., Yarski, M.A., McGrath, B., Burrell, L.M. and Lew, R.A. (2007) Quenched Fluorescent Peptide Substrates as Tools for the Discovery of Novel Cardiovascular Disease Biomarkers.  Amercian Peptide Symposium, Montreal, Canada, 2007.

Smith, D.J., Howden, B.P., Mansell, A.S., Davies, J.K. and Nagley, P.  (2007) Vancomycin-insensitive Staphylococcus aureus may not stimulate an effective host innate immune response as a consequence of reduced TLR signalling. Australian Society for Immunology, Sydney, New South Wales, 2007.

Soo, K.Y., Atkin, J.D., Horne, M.K. and Nagley, P. (2007) Role of aggregated SOD1 proteins in motor neuron disease: recruitment of mitochondria into apoptotic signalling.  7th IBRO World Congress of Neuroscience, Melbourne, Victoria, 2007.

Soo, K.Y., Atkin, J.D., Horne, M.K. and Nagley, P. (2007) Role of normal and mutant SOD1 proteins and the involvement of mitochondria in apoptotic signalling in motor neuron-like cells. 18th International Symposium on ALS/MND, Toronto, Canada, 2007.

Srikram, A., Bulach, D., Wongratanacheewin, S., Adler, B. and Sermswan, R. (2007) Evaluation of predicted outer membrane lipoproptreins as potential vaccine candidates.  5th Scientific Meeting of the International Leptospirosis Society, Quito, Ecuador, 2007.

Steen, J., Harper, M., Wilkie, I.W., Adler, B. and Boyce, J.D. (2007) Signature-tagged mutagenesis of Pasteurella multocida in the natural chicken host using a trans-mucosal infection model.  9th Australian Bacterial Pathogenesis Meeting, Lorne, Australia, 2007.

Stinear, T., Harrison, P., Seemann, T., Jenkin, G.A., Small, P.L.C, Ramakrishnan, L., Johnson, P.D.R., Davies, J.K., Cole, S.T. and Parkhill, J. (2007) The complete genome sequence of Mycobacterium marinum.  9th Australian Bacterial Pathogenesis Conference, Lorne, Victoria, 2007.

Teng, W.L., Bannam, T.L. and Rood, J.I.  (2007) Functional characterisation and localisation of the pCW3-encoded TcpH conjugation protein.  9th Australian Bacterial Pathogenesis Conference, Lorne, Victoria, 2007. 

Tobias, N.J., Hatzinisiriou, I., Jenkin, G.A., Davies, J.K. and Stinear, T.P. (2007) Transcriptional analysis of the mycolactone polyketide synthase locus. Poster presentation by NJ Tobias.  9th Australian Bacterial Pathogenesis Conference, Lorne, Victoria, 2007.

Turcic, K., Rosado, C., Mijaljica, D., Devenish, R.J. and Prescott, M. (2007) Putting organelles on the menu: selective turnover of mitochondria in yeast.  32nd Annual Lorne Conference on Protein Structure and Function, Lorne, Victoria, 2007.

Turcic, K., Rosado, C., Mijaljica, D., Prescott, M. and Devenish, R.J. (2007) Selective turnover of mitochondria in yeast.  23rd International Conference on Yeast Genetics and Molecular Biology, Melbourne, Victoria, 2007.

Turner, S.A., Lyons-Schindler, S., Kahler, C. and Davies, J.K.  (2007) The role of IHF and NMB0398 in Neisseria meningitidis gene regulation.  9th Australian Bacterial Pathogenesis Conference, Lorne Victoria, 2007.

Vaz, P., Bannam T.L., Moore, R., Adler, B., Rood, J.I. and Boyce, J.D.  (2007) Vaccine potential of surface exposed and secreted proteins from a necrotic enteritis strain of Clostridium perfringens.  9th Australian Bacterial Pathogenesis Conference, Lorne, Victoria, 2007.

Witchell, T., Bulach, D. and Adler, B. (2007) Comparison of surface-exposed outer membrane proteins of Brachyspira species. 7th Awaji International Forum on Infection and Immunity, Awaji, Japan, 2007.

Witchell, T., Bulach, D.M. and Adler, B. (2007) Comparison of surface-exposed outer membrane proteins of Brachyspira species.  9th Australian Bacterial Pathogenesis Meeting, Lorne, Australia, 2007.

Wong, W.C., Porter, J., Kennan, R.M., Parker, D., Buckle, A.M., Law, R.H.,  McGowan, S., Rood, J.I. and Whisstock, J.C.  (2007) A disulphide tethered loop confers elastase-like activity on the subtilisin like protease AprV2. Australian Society for Microbiology, Annual Scientific Meeting, Adelaide, South Australia, 2007.