2004 Refereed Papers

*T. Beddoe, S.R. Bushell, M.A. Perugini, T. Lithgow, T.D. Mulhern, S.P. Bottomley, and J. Rossjohn. (2004). A biophysical analysis of the TPR-rich mitochondrial import receptor, Tom70, reveals an elongated monomer that is inherently flexible, unstable and unfolds via a multi-state pathway. Journal of Biological Chemistry , 279: 46448-46454.

*P.D. Gavin, M. Prescott, S.E. Luff and R.J. Devenish. (2004). Cross-linking ATP synthase complexes in vivo eliminates mitochondrial cristae. Journal of Cell Science, 117: 2333-2343.

*J. Irving, D. Askew and J. Whisstock. (2004). Computational analysis of evolution and conservation in a protein superfamily. Methods, 32: 73-92.

*K.F. Fulton, S. Ervine, N. Fauz, R. Forster, R.A. Jodun, W. Ly, L. Robilliard, J Sonsini, D. Whelan, J.C. Whisstock, and A.M. Buckle. (2004).  CLIMS: Crystallography Laboratory Information Management System, Acta Crystallographica Section D Biological Crystallography, 60: 1691-1693.

*J.C. Whisstock and A.M. Lesk. (2003). Prediction of protein function from protein sequence and structure. Quarterly Reviews Of Biophysics. 36: 307-340.

*A.S. Konagurthu, J. Whisstock and P.J. Stuckey. (2004). Progressive multiple alignment using sequence triplet optimizations and three-residue exchange costs. Journal of Bioinformatics and Computational Biology, 2: 719-745.

*J. Boyce, P. Cullen and B. Adler. (2004). Genomic-scale analysis of bacterial gene and protein expression in the host. Emerging Infectious Diseases, 10: 1357-1362.

*M. Harper, A. Cox, F. St Michael, I. Wilkie, J. Boyce and B. Adler. (2004). A heptosyltransferase mutant of Pasteurella multocida produces a truncated lipopolysaccharide structure and is attenuated in virulence. Infection and Immunity, 72: 3436-3443.

*J. Boyce, I. Wilkie, M. Harper, M. Paustian, V. Kapur and B. Adler. (2004). Genomic-scale analysis of Pasteurella multocida gene expression during growth within liver tissue of chickens with fowl cholera. Microbes and Infection, 6: 290-298.

*P. Cullen, D. Haake and B. Adler  (2004). Outer membrane proteins of pathogenic spirochetes, FEMS Microbiology Reviews, 28: 291-318.

*M. Lo, J. Boyce, I. Wilkie and B. Adler.  (2004). Characterization of two lipoproteins in Pasteurella multocida. Microbes and Infection, 6: 58-67.

*T. Bannam, P. Johanesen, C. Salvado, S. Pidot, K. Farrow and J. Rood.  (2004). The Clostridium perfringens TetA(P) efflux protein contains a functional variant of the Motif A region found in major facilitator superfamily transport proteins. Microbiology, 150: 127-134.

*S. Sheedy, A. Ingham, J. Rood and R. Moore.  (2004). Highly conserved alpha-toxin sequences of avian isolates of Clostridium perfringens. Journal of Clinical Microbiology , 42: 1345-1347.

G. Silverman, J. Whisstock, D. Askew, S. Pak, C. Luke, S. Cataltepe, J. Irving and P. Bird. (2004).  Human clade B serpins (ov-serpins) belong to a cohort of evolutionary dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis. Cellular and Molecular Life Sciences, 61: 301-325.

J. Melton, M. Parker, J. Rossjohn, J. Thomas Buckley, R. Tweten. (2004). The identification and structure of the membrane-spanning domain of the Clostridium septicum alpha toxin. Journal of Biological Chemistry, 279: 14315-14322.

J. Pereira, T. Meyer, S. Docherty, H. Reid, J. Marshall, E. Thompson, J. Rossjohn and J. Price. (2004). Biomolecular interaction of insulin-like growth factor (IFG) binding protein-2 with alphavbeta3 negatively modulates IG mediated migration and tumor growth (1), Cancer Research, 64: 977-984.

M. Webb, M. Dunstone, W. Chen, M.I. Aguilar, Q. Chen, H. Jackson, L. Chang, L. Kjer-Nielsen, T. Beddoe, J. McCluskey, J. Rossjohn and A. Purcell. (2004). Functional and structural characteristics of NY-ESO-1 related HLA-A2 restricted epitopes and the design of a novel immunogenic analogue, Journal of Biological Chemistry, 279: 23438-23446.

L. Kjer-Nielsen, M. Dunstone, L. Kostenko, L. Ely, T. Beddoe, N. Mifsud, A. Purcell, A. Brooks, J. McCluskey, and J. Rossjohn. (2004).  Crystal structure of the human T cell receptor CD3 e g heterodimer complexed to the therapeutic mAb OKT3. Proceedings of theNationalAcademyof Sciences of theUnited States of America, 101: 7675-7680.

A.I. Webb, N.A. Borg, M.A. Dunstone, L. Kjer-Nielsen, T. Beddow, J. McCluskey, F.R. Carone, S.P. Bottomley, M-I. Aguilar, A.W. Purcell, and J. Rossjohn. (2004).  The Structure of H-2K(b) and K(bm8) Complexed to a Herpes Simplex Virus Determinant: Evidence for a Conformational Switch That Governs T Cell Repertoire Selection and Viral Resistance. Journal of Immunology, 173: 402-409. 

D. Zernich, A.W. Purcell, W.A. MacDonald, L. Kjer-Nielsen, L.A. Ely, N. Laham, T. Crockford, N.A. Mifsud, M. Bharadwaj, L. Chang, B.D. Tait, R. Holdsworth, A.G. Brooks, S.P. Bottomley, T. Beddoe , C.A. Peh, J. Rossjohn, and J. McCluskey. (2004). Natural HLA Class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion. Journal of Experimental Medicine, 200: 13-24.

M.A. Dunstone, L. Kjer-Nielsen, L. Kostenko, A.W. Purcell, A.G. Brooks, J. Rossjohn and J.M. McCluskey. (2004). The production and purification of the human T-cell receptors, the CD3 e g and the CD3 e d heterodimers: complex formation and crystallization with OKT3, a therapeutic monoclonal antibody. Acta Crystallographica Section D – Biological Crystallography, 60: 1425-1428.

J. McCluskey, J. Rossjohn, and A.W. Purcell. (2004).  TAP genes and immunity. Current Opinion in Immunology, 16: 651-659.

L.N. Benning, J.C. Whisstock, J. Sun, P.I. Bird, and S.P. Bottomley. (2004). The human serpin proteinase inhibitor-9 self-associates at physiological temperatures. Protein Science, 13: 1859-1864. 

M.K.M. Chow, J.P. Mackay, J.C. Whisstock, M.J. Scanlon, and S.P. Bottomley. (2004). Structural and functional analysis of the Josephin domain of polyglutamine protein ataxin-3. Biochemical and Biophysical Research Communications, 322: 387-394.

N. Quinsey, A. Greedy, S. Bottomley , J. Whisstock and R. Pike. (2004). Antithrombin: In control of coagulation. International Journal of Biochemistry & Cell Biology, 36: 386-389.

F. Rosenfeldt, F. Miller, P. Nagley, A. Hadj, S. Marasco, D. Quick, F. Sheeran, M. Wowk, and S. Pepe. (2004). Response of the senescent heart to stress. Clinical therapeutic strategies and quest for mitochondrial predictors of biological age. Annals of the New York Academy of Sciences,  1019: 78-84.

S. Luck, S. Turner, K Rajakumar, B. Adler and H. Sakellaris. (2004).  Excision of the Shigella resistance locus pathogenicity island in Shigella flexneri is stimulated by a member of a new subgroup of recombination directionality factors.  Journal of Bacteriology, 186: 5551-5554.

N. Que-Gewirth, A. Ribeiro, S. Kalb, R. Cotter, D. Bulach, B. Adler, I. St Girons, C. Werts and C. Raetz. (2004). A methylated phasphate group and four amide-linked acyl chains in Leptospira interrogans Lipid A: The membrane anchor of an unusual lipopolysaccharide that activates TLR2, Journal of Biological Chemistry, 279: 25420-25429.

H. Sakellaris, S. Luck, K. Al-Hasani, K. Rajakumar, S. Turner and B. Adler.  (2004). Regulated site-specific recombination of the she pathogenicity island of Shigella flexneri. Molecular Microbiology, 52: 1329-1336.

S. Turner, S. Luck, H. Sakellaris, K. Rajakumar and B. Adler.  (2004). Role of attP in integrase-mediated integration of the Shigella resistance locus pathogenicity island of Shigella flexneri, Antimicrobial Agents and Chemotherapy, 48: 1028-1031.

T. Haselhorst, J. Wilson, R. Thomson, S. McAtamney, J. Menting, R. Coppel and M. von Itzstein.  (2004). Saturation transfer difference (STD) 1H-NMR Experiments and in silico docking experiments to probe the binding of n-acetylneuraminic acid and derivatives to Vibrio cholerae sialidase. Proteins: Sturcture, Function, and Bioinformatics, 56: 346-353.

T. Mao, P. Davis, J. Odin, R. Coppel and M. E. Gershwin. (2004). Sidechain biology and the immunogenicity of PDC-E2, the major autoantigen of primary biliary cirrhosis, Hepatology, 40: 1241-1248.

A. Topolska, C. Black and R. Coppel. (2004). Identification and characterisation of RAMA homologues in rodent, simian and human malaria species, Molecular & Biochemical Parasitology, 138: 237-241.

B. Cooke and R. Coppel.  (2004). Blue skies or stormy weather: what lies ahead for malaria research? Trends in Parasitology, 20:  611-614.

R. Coppel, D. Roos and Z. Bozdech. (2004). The genomics of malaria infection, Trends in Parasitology, 20: 553-557.

C. Black, L. Wang, A. Topolska, D. Finkelstein, M. horne, A. Thomas, N. Mohandas and R. Coppel.  (2004). Merozoite surface proteins 4 and 5 of Plasmodium knowlesi have differing cellular localisation and association with lipid rafts. Molecular & Biochemical Parasitology. 138: 153-158.

L. Wang, D. Webster, S. Wesselingh and R. Coppel.  (2004). Orally delivered malaria vaccines: not too hard to swallow. Expert Opinion on Biological Theraphy, 4: 1585-1594.

L. Wang, M. Goschnick and R. Coppel.  (2004). Oral immunization with a combination of Plasmodium yoelii merozoite surface proteins 1 and 4/5 enhances protection against lethal malaria challenge. Infection and Immunity, 72: 6172-6175.

M. Goschnick, C. Black, L. Kedzierski, A. Holder and R. Coppel.  (2004). Merozoite surface protein 4/5 provides protection against lethal challenge with a heterologous malaria parasite strain, Infection and Immunit , 72: 5840-5849.

C. Selmi, S. Ross, A. A. Ansari, P. Invernizzi, M. Podda, R. Coppel and M. E. Gershwin. (2004). Lack of immunological or molecular evidence for a role of mouse mammary tumor retrovirus in primary biliary cirrhosis. Gastroenterology, 127: 493-501.

A. Topolska, T. Richie, D. Nhan and R. Coppel. (2004). Associations between responses to the rhoptry-associated membrane antigen of Plasmodium falciparum and immunity to malaria infection, Infection and Immunity, 72: 3325-3330.

C. Selmi, S. Ross, A. A. Ansari, P. Invernizzi, M. Podda, R. Coppel and M. E. Gershwin.  (2004). Lack of immunological or molecular evidence for a role of mouse mammary tumor retrovirus in primary biliary cirrhosis. Gastroenterology, 127: 493-501.

K. Amano, P. Leung, Q. Xu, J. Marik, C. Quan, M. Kurth, M. Nantz, A. A. Ansari, K. Lam, M. Zeniya, R. Coppel and M. E. Gershwin. (2004). Xenobiotic-induced loss of tolerance in rabbits to the mitochondrial autoantigen of primary biliary cirrhosis is reversible. Journal of Immunology, 172:  6444-6452.

C. Selmi, P. Invernizzi, E. Keefe, R. Coppel, M. Podda, L. Rossaro, A. A. Ansari and M. E. Gershwin.  (2004). Epidemiology and pathogenesis of primary biliary cirrhosis. Journal of Clinical Gastroenterology, 38: 264-271.

S. Matsumura, J. Van de Water, P. Leung, J. Odin, K. Yamamoto, G. Gores, K. Mostov, A. A. Ansari, R. Coppel, Y. Shiratori and M. E. Gershwin. (2004). Caspase induction by IgA antimitochondrial antibody: IgA-mediated biliary injury in primary biliary cirrhosis. Hepatology, 39: 1415-1422.

B. Cooke, N. Mohandas and R. Coppel. (2004). Malaria and the red blood cell membrane. Seminars in Hematology, 41: 173-188.

K. Tsuji, Y. Watanabe, H. Kouno, Y. Aisaka, T. Masanaga, H. Ishihara, M. Kamiyasu, T. Nakanishi, K. Chayama, T. Asahara, R. Coppel and M. E. Gershwin.  (2004). A case of latent primary biliary cirrhosis. Hepatology Research, 28: 166-169.

A. Topolska, A. Lidgett, D. Truman, H. Fujioka and R. Coppel. (2004). Characterization of a membrane-associated rhoptry protein of Plasmodium falciparum. Journal of Biological Chemistry, 279: 4648-4656.

Y. Kimura, C. Selmi, P. Leung, T. Mao, J. Schauer, M. Watnik, S. Kuriyama, M. Nishioka, A. A. Ansari, R. Coppel, P. Invernizzi, M. Podda and M. E. Gershwin.  (2004). Genetic polymorphisms influencing xenobiotic metabolism and transport in patients with primary biliary cirrhosis.Hepatology, 41: 55-63.

Y. Ichiki, P. Leung, H. Ishibashi, R. Coppel, A. A. Ansari and M. E. Gershwin.  (2004). Mitochondria and autoimmunity in primary biliary cirrhosis. Mitochondrion, 4: 743-753.

L. Snyder, J. Davies and N. Saunders. (2004). Microarray genomotyping of key experimental strains of Neisseria gonorrhoeae revelas gene complement diversity and five new neisserial genes associated with Minimal Mobile Elements. BMC Genomics, 5: 1-12.

Y-L. Tzeng, A. Datta, K. Ambrose. M. Lo, J. Davies, R. Carlson, D. Stephens and C. Kahler.  (2004). The MisR/MisS Two-component regulatory system influences inner core structure and immunotype of lipooligosaccharide in Neisseria meningitidis. Journal of Biological Chemistry, 279:  35053-35062.

L. Laskos, C. Ryan, J. Fyfe and J. Davies.  (2004). The RpoH-mediated stress response in Neisseria gonorrhoeae is regulated at the level of activity. Journal of Bacteriology, 186:  8443-8452.

T. Stinear, A. Mve-Obiang, P. Small, W. Frigui, M. Pryor, R. Brosch, G. Jenkin, P. Johnson, J. Davies, R. Lee, s. adusumilli, T. Garnier, S. Haydock, P. Leadlay and S. Cole. (2004). Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans. Proceedings of theNationalAcademyof Sciences of theUnited States of America. 101: 1345-1349.

K. Granger, R. Moore, J. Davies, J. Vaughan, P. Stiles, D. Stewart and M. Tizard. (2004). Recovery of Mycobacterium avium subspecies paratuberculosis from the natural host for the extraction and analysis in vivo-derived RNA. Journal of Microbiological Methods, 57: 241-249.

D. Lyras, V. Adams, I. Lucent and J. Rood.  (2004). The large resolvase TpX is the only transposon-encoded protein required for transposition of the Tn4451/3 family of integrative mobilizable elements. Molecular Microbiology, 51: 1787-1800.

J. Cheung, B. Dupuy, D. Deveson and J. Rood. (2004). The spatial organization of the VirR boxes is critical for VirR-mediated expression of the perfringolysin O gene, pfoA, from Clostridium perfringens. Journal of Bacteriology, 186: 3321-3330.