2005 Refereed Papers

*Boucher DJ, Adler B & Boyce JD., The Pasteurella multocida nrfE gene is up-regulated during infection and is essential for nitrite reduction, but not for virulence, Journal of Bacteriology, 187, 2278-2285 (2005).

*Chung JY, Wilkie I, Boyce JD & Adler B., Vaccination against fowl cholera with acapsular Pasteurella multocida A:1, Vaccine, 23, 2751-2755 (2005).

*St Michael F, Li J, Vinogradov E, Larocque S, Harper M & Cox AD., Structural analysis of the lipopolysaccharide of Pasteurella multocida strain VP161: identification of both Kdo-P and Kdo-Kdo species in the lipopolysaccharide, Carbohydrate Research, 340, 59-68 (2005).

*Matsoso, L. G., Kana, B. D., Crellin, P. K., Lea-Smith, D. J., Pelosi, A., Powell, D., Dawes, S. S., Rubin, H., Coppel, R. L. & Mizrahi, V., Function of the cytochrome bc1-aa3 branch of the respiratory network in mycobacteria and network adaptation occurring in response to its disruption, Journal of Bacteriology, 187, 6300-6308 (2005).

*Gavin, P., Prescott, M. & Devenish, R.J., Yeast F1FO-ATP synthasecomplex interactions in vivo can occur in the absence of the dimer specific subunit e, Journal of Bioenergetics and Biomembranes, 37, 55-66 (2005).

*Parker, D., R. M. Kennan, G. S. Myers, I. T. Paulsen & J. I. Rood., Identification of a Dichelobacter nodosus ferric uptake regulator and determination of its regulatory targets, Journal of Bacteriology, 187: 366-375 (2005).

*Sayeed, S, M. Miyakawa, D. J. Fisher, V. Adams, R. Poon, J. Rood, F. Uzal & B. A. McClane., Epsilon toxin is required for most Clostridium perfringens type D vegetative culture supernatants to cause lethality in the mouse intravenous injection model, Infection and Immunity, 73: 7413-7421 (2005).

*Marland Z, Beddoe T, Zaker-Tabrizi L, Coppel R.L., Crellin P.K & Rossjohn J., Expression, purification, crystallization and preliminary X-ray diffraction analysis of an essential lipoprotein implicated in cell-wall biosynthesis in Mycobacteria, Acta Crystallographica, Section F 61, 1081-1083 (2005).

*Amin AA, Faux NG, Fenalti, G,Williams, G, Bernadou A, Daglish, B, Keefe K, Middleton, S, Rae, J, Tetis, K, Law, RH, Fulton KF, Rossjohn J, Whisstock JC & Buckle AM, Managing and mining protein crystallization data, Proteins: Structure, Function and Bioinformatics, 62, 4-7 (2005).

*Buckle, A.M., G.L. Devlin, R.A. Jodun, K.F. Fulton, N. Faux, J.C. Whisstock & S.P. Bottomley, The matrix refolded, Nature Methods, 2, 3 (2005).

*Chow, M.K., A.A. Amin, K.F. Fulton, J.C. Whisstock, A.M. Buckle & S.P. Bottomley., REFOLD: An analytical database of protein refolding methods, Protein Expression and Purification, 46, 166-171 (2005).

*M.K. Chow, A.A. Amin, K.F. Fulton, J.C. Whisstock, A.M. Buckle & S.P. Bottomley, The REFOLD database: a tool for the optimization of protein expression and refolding, Nucleic Acids Research, 34 207-212 (2006).

*Chen, Y., B. A. McClane, D. J. Fisher, J. I. Rood & P. Gupta, Construction of an alpha toxin gene knockout mutant of Clostridium perfringens type A using a mobile group II intron, Applied Environmental Microbiology, 71, 7542-7547 (2005).

Faux, N.G., S.P. Bottomley, A.M. Lesk, J.A. Irving, J.R. Morrison, M.G.de la Banda & J.C. Whisstock, Functional insights from the distribution and role of homopeptide repeat-containing proteins, Genome Research, 15, 537-551 (2005).

Adlowitz DG, Sethi S, Cullen PA, Adler B & Murphy TM, Human antibody response to outer membrane protein G1a, a lipoprotein of Moraxella catarrhalis, Infection and Immunity, 73, 6601-6607 (2005).

Cuñe J, Cullen P, Mazon G, Campoy S, Adler B & Barbe J, The Leptospira interrogans lexA gene is not autoregulated, Journal of Bacteriology, 187, 5841-5845 (2005).

Cullen PA, Xu X, Matsunaga J, Sanchez Y, Ko AI, Haake DA & Adler B, Surfaceome of Leptospira spp, Infection and Immunity, 73, 4853-4863 (2005).

F. Rosenfeldt, S. Marasco, W. Lyon, M. Wowk, F. Sheeran, M. Bailey, D. Esmore, B. Davis, A. Pick, M. Rabinov, J. Smith, P. Nagley & S. Pepe, Coenzyme Q10 therapy before cardiac surgery improves mitochondrial and myocardial contractile function, Journal of Thoracic and Cardiovascular Surgery, 129, 25-32 (2005).

Y. Wang, V.W.S. Liu, P.C.K. Tsang, P.M. Chiu, A.N.Y. Cheung, U.S. Khoo, P. Nagley & H.Y. S. Ngan, Microsatellite instability in mitochondrial genome of common female cancers, International Journal of Gynaecological Cancer, 6, 259-266 (2005).

Y. Wang, V.W.S. Liu, H.Y.S. Ngan & P. Nagley, Frequent occurrence of mitochondrial microsatellite instability in D-loop region of human cancers, Annals of the New York Academy of Sciences, 1042, 123-129 (2005).

Padgett, K. A., Selmi, C., Kenny, T. P., Leung, P. S., Balkwill, D. L., Ansari, A. A., Coppel, R. L. & Gershwin, M. E., Phylogenetic and immunological definition of four lipoylated proteins from Novosphingobium aromaticivorans, implications for primary biliary cirrhosis, Journal of Autoimmunity, 24, 209-219 (2005).

Amano, K., Leung, P. S., Rieger, R., Quan, C., Wang, X., Marik, J., Suen, Y. F., Kurth, M. J., Nantz, M. H., Ansari, A. A., Lam, K. S., Zeniya, M., Matsuura, E., Coppel, R. L. & Gershwin, M. E., Chemical Xenobiotics and Mitochondrial Autoantigens in Primary Biliary Cirrhosis: Identification of Antibodies against a Common Environmental, Cosmetic, and Food Additive, 2-Octynoic Acid, Journal of Immunology, 174, 5874-5883 (2005).

Coppel, R. L. & Black, C. G., Parasite genomes, International Journal of Parasitology, 35, 465-479 (2005).

Kimura, Y., Selmi, C., Leung, P. S., Mao, T. K., Schauer, J., Watnik, M., Kuriyama, S., Nishioka, M., Ansari, A. A., Coppel, R. L., Invernizzi, P., Podda, M. & Gershwin, M. E., Genetic polymorphisms influencing xenobiotic metabolism and transport in patients with primary biliary cirrhosis, Hepatology, 41, 55-63 (2005).

Kikuchi, K., Lian, Z. X., Yang, G. X., Ansari, A. A., Ikehara, S., Kaplan, M., Miyakawa, H., Coppel, R. L. & Gershwin, M. E., Bacterial CpG induces hyper-IgM production in CD27(+) memory B cells in primary biliary cirrhosis, Gastroenterology, 128, 304-312 (2005).

Kikuchi, K., Lian, Z. X., Kimura, Y., Selmi, C., Yang, G. X., Gordon, S. C., Invernizzi, P., Podda, M., Coppel, R. L., Ansari, A. A., Ikehara, S., Miyakawa, H. & Gershwin, M. E., Genetic polymorphisms of toll-like receptor 9 influence the immune response to CpG and contribute to hyper-IgM in primary biliary cirrhosis, Journal of Autoimmunity, 24, 347-352 (2005).

Pei, X., An, X., Guo, X., Tarnawski, M., Coppel, R. & Mohandas, N., Structural and functional studies of interaction between Plasmodium falciparum knob-associated histidine-rich protein (KAHRP) and erythrocyte spectrin, Journal of Biological Chemistry, 280, 31166-31171 (2005).
Wang, L., Kedzierski, L., Schofield, L. & Coppel, R. L., Influence of glycosylphosphatidylinositol anchorage on the efficacy of DNA vaccines encoding Plasmodium yoelii merozoite surface protein 4/5, Vaccine, 23, 4120-4127 (2005).

Myers, B., Dix, T., Coppel, R. & Green, D. Database Integration and Querying in the Bioinformatics Domain, In: The ICWE 2005 Workshop on Web Information Systems Modelling, (eds. Frasicar, F., Houben, G.-J. & Vdovjak, R.). University of Wollongong, School of IT and Computer Science, Sydney. pp. 14-20

Black, C. G., Wu, T., Wang, L., Topolska, A. E. & Coppel, R. L., MSP8 is a non-essential merozoite surface protein in Plasmodium falciparum, Molecular & Biochemical Parasitology, 144, 27-35 (2005).

Cooke, B. M., Mohandas, N., Cowman, A. F. & Coppel, R. L., Cellular adhesive phenomena in apicomplexan parasites of red blood cells, Veterinary Parasitology, 132, 273-295 (2005).
Leung, P. S., Coppel, R. L. & Gershwin, M. E., Etiology of primary biliary cirrhosis: the search for the culprit, Seminars in Liver Disease, 25, 327-336 (2005).

Mao, T. K., Lian, Z. X., Selmi, C., Ichiki, Y., Ashwood, P., Ansari, A. A., Coppel, R. L., Shimoda, S., Ishibashi, H. & Gershwin, M. E., Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis, Hepatology, 42, 802-808 (2005).

Pouniotis, D. S., Proudfoot, O., Bogdanoska, V., Scalzo, K., Kovacevic, S., Coppel, R. L. & Plebanski, M., Selectively Impaired CD8+ but Not CD4+ T Cell Cycle Arrest during Priming as a Consequence of Dendritic Cell Interaction with Plasmodium-Infected Red Cells, Journal of Immunology, 175, 3525-3533 (2005).

Chuang, Y. H., Lian, Z. X., Cheng, C. M., Lan, R. Y., Yang, G. X., Moritoki, Y., Chiang, B. L., Ansari, A. A., Tsuneyama, K., Coppel, R. L. & Gershwin, M. E., Increased levels of chemokine receptor CXCR3 and chemokines IP-10 and MIG in patients with primary biliary cirrhosis and their first degree relatives, Journal of Autoimmunity, 25, 126-132 (2005).

Snyder, L.A.S., J.K. Davies, C.S. Ryan & N.J., Saunders. Comparative overview of the genomic and genetic differences between the pathogenic Neisseria strains and species, Plasmid, 54, 191–218 (2005).

Rupnik M., Dupuy B., Fairweather N., Gerding D., Johnson S., Just I., Lyerly D.M., Popoff M.R., Rood J.I., Sonenshein A. L., Thelestam M., Wren B.W., Wilkins T.D. & Eichel-Streiber C., Revised nomenclature of Clostridium difficile toxins and associated genes, Journal of Medical Microbiology, 54, 113-117 (2005).

Kennedy, C., S. Krejany, L. Young, M.M. Awad, R. Boyd, J. Emmins, D. Lyras & J. I. Rood., The a toxin of Clostridium septicum is essential for virulence, Molecular Microbiology, 57, 1357-1366 (2005).

Fulton KF, Buckle AM, Cabrita LD, Irving JA, Butcher RE, Smith A I, Reeve S, Lesk AM, Bottomley SP, Rossjohn J & Whisstock JC., The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition, Journal of Biological Chemistry, 280, 8435-8442 (2005).

Burrell L, Risvanis J, Kubota E, MacDonald P S, Lu S, Tikellis C, Grant S L, Lew R A, Smith A I, Cooper M E & Johnston C I., Myocardial ischemia increases ACE2 expression in rat and man, European Heart Journal, 26, 369-375; discussion 322-324 (2005).

Buzza M S, Zamurs L, Sun J, Bird C H , Smith A I, Trapani J A,. Froelich C J, Nice E C & Bird P I., Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin and laminin, Journal of Biological Chemistry, 280, 23549-23558 (2005).
Blanchfield J T, Lew R A, Smith A I & Toth I., The stability of lipidic analogues of GnRH in plasma and kidney preparations: the stereoselective release of the parent peptide, Bioorganic and Medicinal Chemistry Letters, 15, 1609-1612 (2005).

Paizis G, Tikellis C, Cooper M E, Schembri J M, Lew R A, Smith AI, Shaw T, Warner F J, Zuilli A, Burrell L M & Angus P W., Chronic liver injury in rat and humans upregulates the novel enzyme angiotensin converting enzyme 2, Gut, 54, 1790-1796 (2005).

Kuruppu S, Reeve S, Smith A I & Hodgson W., Isolation and pharmacological characterisation of papuantoxin-1, a postsynaptic neurotoxin from the venom of the Papuan black snake (Pseudechis papuanus), Biochemical Pharmacology, 70, 794-800 (2005).

Lambert DW, Yarski M., Warner FJ, Thornhill P, Parkin ET, Smith AI, Hooper NM & Turner AJ, Tumor necrosis factor-convertase (ADAM17) mediates regulated ectodomain shedding of the SARS-CoV receptor, angiotensin-converting enzyme-2 (ACE2), Journal of Biological Chemistry, 280, 30113-30119 (2005).

Hart AJ, Smith AI, Reeve S. & Hodgson WC, Isolation and characterisation of acanmyotoxin-2 and acanmyotoxin-3, myotoxins from the venom of the death adder Acanthophis sp. Seram, Biochemical Pharmacology, 70, 1807-1813 (2005).

Kuruppu K, Shane Reeve, Banerjee Y, Kini R M, Smith A I & Hodgson W C, Isolation and pharmacological characterisation of cannitoxin, a presynaptic neurotoxin from the venom of the Papuan taipan (Oxyuranus scutellatus canni), Journal of Pharmacology and Experimental Therapeutics, 315, 1196-1202 (2005)

Warner F J, Smith A I, Lew R A, Lambert D W, Hooper N M & Turner A J, Angiotensin-converting enzyme 2(ACE2), but not ACE, is preferentially localised to the apical surface of polarised kidney cells, (Sept 15th 2005, Journal of Biological Chemistry in press).

Borg N.A., Ely L.K., Beddoe T., Macdonald W.A., Reid H.H., Clements C.S., Purcell A.W., Kjer-Nielsen L., Miles J.J., Burrows S.R., McCluskey, J. & Rossjohn, J., The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition, Nature Immunolgy, 6, 171-180 (2005).

Clements, C.S., Kjer-Nielsen, L., Kostenko, L., Hoare, H.L., Dunstone M.A., Moses E., Freed K., Brooks A.G., Rossjohn, J. & McCluskey, J., The crystal structure of HLA-G: a non-classical MHC class I molecule expressed at the fetal-maternal interface, Proceedings of the National Academy of Sciences of the United States of America, 102, 3360-3365 (2005).

Turner, S.J., Kedzierska, K., Komodromou, H., La Gruta, N.L., Dunstone, M.A., Webb, A.I., Webby, R., Walden, H., Xie, W., McCluskey, J., Purcell, A.W., Rossjohn, J. & Doherty, P.C., Lack of prominent peptide/MHC features limits T cell receptor repertoire diversity in virus-specific CD8+ T populations, Nature Immunology, 6, 382-389 (2005).

Ely, L.K., Green, K.J., Beddoe, T., Clements, C.S., Miles, J.J., Bottomley, S.P., Kjer-Nielsen, L., Purcell, A.W., McCluskey, J., Rossjohn, J. & Burrows S.R., Antagonism of antiviral and allogeneic activity of a human public CTL clonotype by a single altered peptide ligand: implications for allograft rejection, Journal of Immunology, 174, 5593-5601 (2005).

Wilmann, P.G., Petersen, J., Pettikiriarachchi, A., Buckle, A.M., Smith, S.C., Olsen, S., Perugini, M.A., Devenish, R.J. Prescott, M. & Rossjohn, J., The 2.1 Å crystal structure of the far-red fluorescent protein HcRed: inherent conformational flexibility of the chromophore, Journal of Molecular Biology, 349, 223-237 (2005).

Law, R.H.P., Irving, J.A., Buckle, A.M., Ruzyla, K., Buzza, M., Bashtannyk-Puhalovich, T.A., Beddoe, T.C., Kim, N., Worrall, M.D., Bottomley, S.P., Bird, P.I., Rossjohn, J. & Whisstock, J.C., The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix, Journal of Biological Chemistry, 280, 22356-22364 (2005).

Tynan F.E., Borg N.A., Miles J.J., Beddoe T., El-Hassen D., Silins S.L., van Zuylen W.J., Purcell A.W., Kjer-Nielsen L., McCluskey J., Burrows S.R. & Rossjohn J.,  High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I. Implications for T-cell receptor engagement and T-cell immunodominance, Journal of Biological Chemistry, 280, 23900-23909 (2005).

Webb, A.I., Dunstone, M.A., Williamson, N.A., Price, J.D., de Kauwe, A., Chen, W., Oakley, A., Perlmutter, P. McCluskey, J., Aguilar, M-I, Rossjohn, J & Purcell, A.W.,  T cell determinants incorporating b-amino acid residues are protease resistant and remain immunogenic in vivo, Journal of Immunology, 175, 3810-3818 (2005).

Miles, J.J, Borg, N.A., El-hassen D., Silins, S.L., Tynan, F.E., Burrows, J.M., Purcell, A.W., Kjer-Nielsen, L., Rossjohn, J., Burrows, S.R. & McCluskey J.,  CTL recognition of a bulged viral peptide involves biased T-cell receptor selection, Journal of Immunology, 175, 3826-3834 (2005).

Horvath, A.J., Irving, J.A., Rossjohn, J., Law, R.H., Bottomley S.P., Quinsey, N.S., Pike, R.N., Coughlin, P.B. & Whisstock, J.C.,The murine orthologue of human antichymotrypsin: A structural paradigm for clade A3 serpins, Journal of Biological Chemistry, 280, 43168-43178 (2005).

Tynan, F.E., Burrows, S.R., Buckle, A.M., Clements, C.S., Borg, N.A., Miles, J.J., Beddoe, T., Whisstock, J.C., Wilce, M.C., Silins, S.L., Burrows, J.M., Kjer-Nielsen, L., Kostenko, L., Purcell, A.W., McCluskey, J. & Rossjohn, J., T cell receptor recognition of a super-bulged MHC-class I bound peptide, Nature Immunology, 6, 1114-1122 (2005).

Tynan, F.E., Elhassen, D., Burrows, J.M., , Borg, N.A., Miles J.J., , Green K.J., Tellam, J. Kjer-Nielsen, L., McCluskey, J., Rossjohn, J. & Burrows, S.R., The Immunogenicity of a Viral Cytotoxic T Cell Epitope is controlled by its MHC-bound Conformation, Journal of Experimental Medicine, 202, 1249-1260 (2005).

Mannering, S.I., Harrison, L.C., Williamson, N.A., Morris, J.S., Thearle, D.J., Jensen, K.P., Kay, T.W.H., Rossjohn, J., Falk, B.A., Nepom, G.T. & Purcell, A.W., The insulin A-chain epitope recognised by human T-cells is post-translationally modified, Journal of Experimental Medicine, 202, 1191-1197 (2005).

Bird, C.H., Sun J., Ung K. Karambalis, D., Whisstock J.C., Trapani J.A. & Bird P.I., Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells, Molecular Cell Biology, 25, 7854-7867 (2005).

Boyd, S.E., Pike R.N., Rudy G.B., Whisstock J.C. & Garcia de laBanda M., PoPS: a computational tool for modeling and predicting protease specificity, Journal of Bioinformatics and Computational Biology, 3, 551-585 (2005).

Ivetac, I., Munday A.D., Kisseleva M.V., Zhang X.M., Luff S., Tiganis T., Whisstock J.C., Rowe T., Majerus P.W. & Mitchell C.A., The type Ialpha inositol polyphosphate 4-phosphatase generates andterminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane. Molecular Biology of the Cell, 16, 2218-2233 (2005).

Kerr, F.K., O'Brien G., Quinsey N.S., Whisstock J.C., Boyd S., Garcia de la Banda M., KaisermanD., Matthews A.Y., Bird P.I. & Pike R.N.  Elucidation of the substrate specificity of the C1s protease of the classical complement pathway, Journal of Biological Chemistry, 280, 39510-39514 (2005).