2007 Refereed Papers

Al-Hasani, K., Boyce J., McCarl V., Bottomley S., Wilkie I., and Adler B. (2007)  Identification of novel immunogens in Pasteurella multocida. Microbial Cell Factories, 6, 3. Link to full text

Aguilar, M.I., Purcell, A.W., Lew, R.D., Rossjohn, J., Smith, A.I. and Perlmutter, P. (2007) Beta-Amino acid-containing hybrid peptides - new opportunities in peptidomimetics. Organic and Biomolecular Chemistry 5, 2884-2890.

Askew, D.J., Cataltepe, S., Kumar, V., Edwards, C., Pace, S.M.,  Howarth, R.N., Pak, S.C., Askew, Y.S., Bromme, D., Luke, C.J., Whisstock, J.C., and Silverman, G.A.  (2007) SERPINB11 is a new non- inhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change. Journal of Biological Chemistry, 282, 24948- 2496.

Battad, J.M., Wilmann, P.G., Olsen, S., Byres, E., Smith, S.C., Dov, S.G., Turcic, K.N., Devenish, R.J., Rossjohn, J., and Prescott, M.  (2007) A structural basis for the pH-dependent increase in fluorescence efficiency of chromoproteins.  Journal of Molecular Biology, 368, 998-1010.

Beart, P.M., Lim, M.L.R., Chen, B., Diwakarla, S., Mercer, L.D., Cheung, N.S. and Nagley, P. (2007)  Hierarchical recruitment by AMPA but not staurosporine of pro-apoptotic mitochondrial Signalling in cultured cortical neurons: evidence for caspase-dependent/independent cross-talk.  Journal of Neurochemistry, 103, 2408-2427.

Borg, N.A., Kjer-Nielsen, L., McCluskey, J. and Rossjohn, J.  (2007) Structural insight into natural killer T cell receptor recognition of CD1d. Advances in Experimental Medical and Biology, 598, 20-34.

Borg, .N.A., Wun, K.S., Kjer-Nielsen, L., Wilce, M.C., Pellicci, D.G., Koh, R., Besra, G.S., Bharadwaj, M., Godfrey, D.I., McCluskey, J., and Rossjohn, J.  (2007)  CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor.  Nature, 448, 44-49.

Buckle, A.M., Abramson, D., Amin, A.A., Bate, M., Beitz, A., Enticott, C., Faux, N., Mahmood, K., Swift, M., Treloar, A., and Whisstock, J.C.  (2007) eResearch solutions for high throughput structural biology.  IEEE Computer Society, 221-227.

Buckle, A.M., Zhang, Q., Law, R.H.,  Pearce, M.C., Cabrita, L.D., Lloyd, G.J., Irving, J.A., Smith, A.I., Ruzyla, K., Rossjohn, J., Bottomley, S.P., and Whisstock, J.C.  (2007) The N-terminus of the serpin Tengpin functions to trap the metastable native state.  EMBO Reports, 8, 658-663. Link to full text

Burrows, J.M., Wynn, K.K., Tynan, F.E., Archbold, J., Miles, J.J., Bell, M.J., Brennan, R.M., Walker, S., McCluskey, J., Rossjohn, J., Khanna, R., and Burrows, S.R.  (2007) The impact of HLA-B micropolymorphism outside primary peptide anchor pockets on the CTL response to CMV. Eur. Journal of Immunology, 37, 946-953.

Carter, G.P., Lyras, D., Allen, D.L, Mackin, K., Howarth, P., O’Connor, J.R. and Rood, J.I.  (2007) Identification of CdtR, a LytTR family response regulator that activates CDT binary toxin production in Clostridium difficile.  Journal of Bacteriology, 189, 7290-7301. Link to full text

Cabrita, L.D, Irving, J.A., Pearce, M.C., Whisstock, J.C., and Bottomley, S.P.  (2007) Aeropin from the extremophile Pyrobaculum aerophilum bypasses the serpin misfolding trap.  Journal of Biological Chemistry, 282, 26802-28609.  (Whisstock and Bottomley joint senior and corresponding author.)

Chandana, B.H, Warner, F.J, Lubel, J.S, Dean, R.G, Zhiyuan, J., Lew, R.A., Smith, A.I., Burrell, L.M., and Angus, P.W.  (2007) Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis.  Journal of Hepatology, 47, 387-395.Clements, C.S., Kjer-Nielsen, L., McCluskey, J., and Rossjohn, J.  (2007) Structural studies on HLA-G: implications for ligand and receptor binding. Human Immunology, 68, 220-226.

Davis, C.B, Hartnell, R.D, Madge, P.D, Owen, D.J, Thomson, R.J, Chong, A.K, Coppel, R.L., and von Itzstein, M.  (2007) Synthesis and biological evaluation of galactofuranosyl alkyl thioglycosides as inhibitors of mycobacteria.  Carbohydrate Research, 342, 1773-1780.

Devenish, R.J. (2007) Mitophagy: Growing in intricacy. Autophagy, 3, 293-294.

Eisen, D.P, Wang, L., Jouin, H., Murhandarwati, E.E., Black, C.G., Mercereau-Puijalon, O., and Coppel, R.L. (2007) Antibodies elicited in adults by a primary Plasmodium falciparum blood-stage infection recognize different epitopes compared with immune individuals.  Malaria Journal, 6, 86. Link to full text

Faux, N.G., Huttley, G.A., Mahmood, K., Webb, G.I, Garcia de la Banda, M., and Whisstock, J.C.  (2007) RCPdb, an evolutionary classification and codon usage database for Repeat Containing Proteins. Genome Research, 17, 1118-11127. Link to full text

Fenalti, G., Law, R.H.P., Buckle, A.M., Langendorf, C., Tuck, K., Rosado, C.J., Faux, N.G., Mahmood, K., Hamp, C.S., Banga P., Wilce M., Schmidberger J., Rossjohn J., El-Kabbani O., Pike, R.N., Smith, A.I., Mackay, I.R., Rowley, M.J., and Whisstock, J.C.  (2007) GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop. Nature Structural and Molecular Biology, 14, 280-286.

Fernandez-Miyakawa, M., Fisher, D.J., Poon, R., Sayeed, S., Adams, V., Rood, J.I., McClane, B.A., and Uzal, F.A.  (2007) Both epsilon-toxin and beta-toxin are important for the lethal properties of Clostridium perfringens type B isolates in the mouse intravenous injection model.  Infection and Immunity, 75, 1443-1452. Link to full text

Fernandez-Miyakawa, M.E., Sayeed, S., Fisher, D.J., Poon, R., Adams, V., Rood, J.I., McClane, B.A., Saputo, J., and Uzal F.A.  (2007) Development and application of a mouse oral challenge model for studying Clostridium perfringens type D infection. Infection and Immunity, 75, 4282-4288. Link to full text

Henderson, K.N., Reid, H.H., Borg, N.A., Broughton, S.E., Huyton, T., Anderson, R.P., McCluskey, J., and Rossjohn J.  (2007) The production and crystallization of the human leukocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 complexed with deamidated gliadin peptides implicated in coeliac disease. Acta Crystallographica Section F Structural Biology and Crystallization Communications, 63, 1021-1025.

Han, X., Kennan, R.M., Parker, D., Davies, J.K., and Rood, J.I.  (2007) Type IV fimbrial biogenesis is required for protease secretion and natural transformation in Dichelobacter nodosus. Journal of Bacteriology, 189, 5022-5033. Link to full text

Harper, M., Boyce, J.D., Cox, A.D., St. Michael, F., Wilkie, I.W., Blackall, P.J., and Adler, B.  (2007) Pasteurella multocida expresses two LPS glycoforms simultaneously but only a single form is required for virulence: identification of two acceptor specific heptosyl I transferases. Infection and Immunity, 75, 3885-3893. Link to full text

Harper, M., Cox, A, St. Michael, F., Parnas, H., Wilkie I., Blackall, P., Adler, B., and Boyce, J.  (2007) Decoration of Pasteurella multocida LPS with phosphocholine is important for virulence. Journal of Bacteriology, 189, 7384-7391. Link to full text

Henderson, K.N., Tye-Din, J.A., Reid, H.H., Chen, Z., Borg, N.A., Beissbarth, T., Tatham, A., Mannering, S.I., Purcell, A.W., Dudek, N.L., van Heel, D.A., McCluskey J., Rossjohn, J.,  and Anderson, R.P.  (2007) A Structural and Immunological Basis for the Role of Human Leukocyte Antigen DQ8 in Celiac Disease.  Immunity, 27, 23-34.

Hughes, M.L., Poon, R., Adams, V., Sayeed, S., Saputo, J., Uzal, F.A., McClane, B.A., and Rood, J.I.  (2007) Epsilon toxin plasmids of Clostridium perfringens Type D are conjugative.  Journal of Bacteriology, 189, 7531-7538. Link to full text

Huyton, T., Rossjohn, J., and Wilce, M.  (2007) Toll-like receptors: structural pieces of a curve-shaped puzzle.  Immunology and Cell Biology, 85, 406-410.

Kuruppu, S., Reeve, S., and Smith, A.I. (2007) Characterisation of endothelin converting enzyme-1 shedding from endothelial cells.  FEBS Letters, 581, 4501-4506.

Law, R.H.P., Sofian, T., Kan, W-T., Horvath, A.J., Hitchen, C.R., Langendorf, C.G., Buckle, A.M., Whisstock, J.C., and Coughlin, P.B.  (2007) The X-ray crystal structure of the fibrinolysis inhibitor and alpha2 antiplasmin. Blood, 111, 2049-2052.

Lea-Smith, D.J., Pyke, J.S., Tull, D., McConville, M.J., Coppel, R.L., and Crellin, P.K. (2007) The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of mycolic acids to arabinogalactan. Journal of Biological Chemistry, 282, 11000-11008.

Leung, P.S., Park, O., Tsuneyama, K., Kurth, M.J., Lam, K.S., Ansari, A.A., Coppel, R.L., and Gershwin, M.E.  (2007)  Induction of primary biliary cirrhosis in guinea pigs following chemical xenobiotic immunization. Journal of Immunology, 179, 2651-2657.

Lleo, A., Invernizzi, P., Selmi, C., Coppel, R.L., Alpini, G., Podda, M., Mackay, I.R., and Gershwin, ME.  (2007) Autophagy: highlighting a novel player in the autoimmunity scenario.  Journal of Autoimmunity, 29, 61-68. Link to full text

Logan, G.J., Wang, L., Zheng, M., Cunningham, S.C., Coppel, R.L., and Alexander, I.E.  (2007) AAV vectors encoding malarial antigens stimulate antigen-specific immunity but do not protect from parasite infection. Vaccine. 25, 1014-1022.

Matsunaga, J., Lo, M., Bulach, D.M., Zuerner, R.L., Adler, B., and Haake, D.A. (2007) Response of Leptospira interrogans to physiologic osmolarity: relevance in Signalling the environment-to-host transition. Infection and Immunity, 75, 2864-2874. Link to full text

McKean, S.C., Davies, J.K. and Moore, R.J.  (2007) Probing the heat shock response of Corynebacterium pseudotuberculosis: the major virulence factor, phospholipase D, is down-regulated at 43oC.  Research Microbiology, 158, 279-286.

McKean, S.C., Davies, J.K., and Moore, R.J.  (2007) Expression of phospholipase D, the major virulence factor of Corynebacterium pseudotuberculosis, is regulated by multiple environmental factors and plays a role in macrophage death.  Microbiology, 153, 2203-2211.

Mercer, L., Nagley, P., and Beart., P.M.  (2007) Rotenone and MPP+ preferentially redistribute apoptosis-inducing factor in apoptotic dopamine neurons. NeuroReport 18, 307-312.

Mijaljica, D., Prescott, M., and Devenish, R.J.  (2007) Different fates of mitochondria: alternative ways for degradation? Autophagy, 3, 4-9.Mijaljica, D., Prescott, M., and Devenish, R.J.  (2007) Nibbling within the nucleus: turnover of nuclear contents. Cellular and Molecular Life Sciences, 64, 581-588.

Mijaljica, D., Prescott, M., Klionsky, D.J., and Devenish, R.J.  (2007) Autophagy and vacuole homeostasis: a case for self-degradation? Autophagy, 3, 417-421.

Moritoki, Y., Lian., Z.X., Wulff, H., Yang, G.X., Chuang, Y.H., Lan, R.Y., Ueno, Y., Ansari, A.A., Coppel, R.L., Mackay, I.R., and Gershwin, M.E.  (2007)  AMA production in primary biliary cirrhosis is promoted by the TLR9 ligand CpG and suppressed by potassium channel blockers.  Hepatology, 45, 314-322.

Myers, G.S.A., Parker, D., Al-Hasani, K., Kennan, R.M., Seemann, T., Ren, Q.H., Badger, J.H., Selengut, J.D., DeBoy, R.T., Tettelin, H., Boyce, J.D., McCarl, V.P., Nelson, W., Madupu, R., Mohamoud, Y., Holley, T., Fedorova, N., Khouri, H., Bottomley, S.P., Whittington, R.J., Adler, B., Songer, J.G., Rood, J.I., and Paulsen, I.T. (2007) Genome sequence and identification of candidate vaccine antigens from the animal pathogen Dichelobacter nodosus.  Nature Biotechnology, 25, 569-575.

Nowikovsky, K., Reipert, S., Devenish, R.J., and Schweyen, R.J.  (2007) Mdm38 protein depletion causes loss of mitochondrial K+/H+ exchange activity, osmotic swelling and mitophagy.  Cell Death and Differentiation, 14, 1647-1656.

Oertelt, S., Ridgway, W.M., Ansari, A.A., Coppel, R.L., and Gershwin, M.E.  (2007)  Murine models of primary biliary cirrhosis:  Comparisons and contrasts.  Hepatology Research, 37, S365-369.

Oertelt, S., Rieger, R., Selmi, C., Invernizzi, P., Ansari, A.A., Coppel, R.L., Podda, M., Leung, P.S, and Gershwin, ME.  (2007)  A sensitive bead assay for antimitochondrial antibodies: Chipping away at AMA-negative primary biliary cirrhosis.  Hepatology, 45, 659-665.

Ong, P., McGowan, S., Pearce, M.C., Irving, J.A., Kan, W-T., Grigoryev, S.A., Turk, B., Silverman, G.A., Brix, K., Bottomley, S.P., Whisstock, J.C., and Pike, R.N.  (2007)  DNA accelerates the inhibition of human cathepsin V by serpins. Journal of Biological Chemistry, 282, 36980-36986.

Owen, D.J., Davis, C.B., Hartnell, R.D., Madge, P.D., Thomson, R.J., Chong, A.K., Coppel, R.L., and von Itzstein, M.  (2007)  Synthesis and evaluation of galactofuranosyl N, N-dialkyl sulfenamides and sulfonamides as antimycobacterial agents.  Bioorganic & Medicinal Chemistry Letters, 17, 2274.

Parsons, J.A., Bannam, T.L., Devenish, R.J., and Rood, J.I.  (2007) TcpA, an FtsK/SpoIIIE homolog, is essential for transfer of the conjugative plasmid pCW3 in Clostridium perfringens.  Journal of Bacteriology, 189, 7782-7790. Link to full text

Pei, X., Guo, X., Coppel, R., Bhattacharjee, S., Haldar, K., Gratzer, W., Mohandas N., and An, X.  (2007)  The ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum stabilizes spectrin tetramers and suppresses further invasion.  Blood, 110, 1036-1042. Link to full text

Pei, X., Guo, X., Coppel, R., Mohandas, N., and An, X.  (2007)  Plasmodium falciparum erythrocyte membrane protein 3 (PfEMP3) destabilizes erythrocyte membrane skeleton.  Journal of Biological Chemistry, 282, 26754-26758.

Porter, C.J., Schuch, R., Pelzek, A.J., Buckle, A.M., Wilce, M.C., Rossjohn, J., Russell, R., Nelson, D., Fischetti, V.A., and Whisstock, J.C. (2007)  The 1.6 Å crystal structure of the catalytic domain of PlyB, a bacteriophage lysin active against Bacillus anthracis.  Journal of Molecular Biology, 366, 540-550.

Proellocks, N.I., Kovacevic, S., Ferguson,,D.J., Kats, L.M., Morahan, B.J., Black, C.G., Waller, K.L., and Coppel, R.L. (2007)  Plasmodium falciparum Pf34, a novel GPI-anchored rhoptry protein found in detergent-resistant microdomains.  International Journal of Parasitology, 37, 1233-1241.

Purcell, A.W., McCluskey, J., and Rossjohn, J.  (2007)  More than one reason to rethink the use of peptides in vaccine design. Nature Reviews Drug Discovery, 6, 404-414.

Rosado, C.J., Buckle, A.M., Law, R.H.P., Butcher, R.E., Kan, W-T., Bird, C.H., Ung, K., Browne, K.A., Baran, K., Bashtannyk-Puhalovich, T.A., Faux, N.G., Wong, W., Porter, C.J., Pike, R.N., Ellisdon, A.M., Pearce, M.C., Bottomley, S.P., Emsley, J., Smith, A.I., Rossjohn, J., Hartland, E.L., Voskoboinik, I., Trapani, J.A., Bird, P.I., Dunstone, M.A., and Whisstock, J.C.  (2007)  A common fold mediates vertebrate defense and bacterial attack.  Science, 317, 1548-1551. Rossjohn, J., and McCluskey, J.  (2007)  A home grown receptor interacts with a foreign landscape.  Cell, 129, 19-20.

Rossjohn, J., Polekhina, G., Feil,  S.C., Morton, C.J., Tweten, R.K., and Parker, M.W.  (2007) Structures of Perfringolysin O Suggest a Pathway for Activation of Cholesterol-dependent Cytolysins.  Journal of Molecular Biology, 367, 1227-1236.

Scott, F.L., Sun, J., Whisstock, J.C., Kato, K. and Bird, P.I.  (2007)  SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes.  Journal of Biochemistry, 142, 435-442.

Scott-Browne, J.P., Matsuda, J.L., Mallevaey, T., White, J., Borg, N.A., McCluskey, J., Rossjohn, J., Kappler, J., Marrack, P., and Gapin, L..  (2007) Germline encoded recognition of diverse glycolipids by NKT cells. Nature Immunology, 8, 1105-1113.

Stinear, T.P., Pidot, S., Frigui, W., Meurice, G., Reysett, G., Garnier, T., Bouchier, C.,  Ma, L., Tichit, M., Porter, J.L., Ryan, J., Johnson, P.D.R., Davies, J.K., Jenkin, G.A., Seemann, T., Small, P.L.C., Laval, F., Daffe, M., Parkhill, J., and Cole, S.T.  (2007) Recent adaptation to a changed environment inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer.  Genome Research, 17, 192-200.

Sullivan, L.C., Clements, C.S., Beddoe, T., Johnson, D., Hoare, H.L., Lin, J., Huyton, T., Hopkins, E.J., Reid, H.H., Wilce, M.C., Kabat, J., Borrego, F., Coligan, J.E., Rossjohn, J., and Brooks, A.G.  (2007) The Heterodimeric Assembly of the CD94-NKG2 Receptor Family and Implications for Human Leukocyte Antigen-E Recognition.  Immunity, 27, 900-911.

Tynan, F.E., Reid, H.H., Kjer-Nielsen, L., Miles, J.J., Wilce, M.C., Kostenko, L.,  Borg, N.A., Williamson, N.A., Beddoe, T., Purcell, A., Burrows, S.R., McCluskey, and Rossjohn, J.  (2007) A T cell receptor flattens a bulged antigenic peptide presented by a class I major histocompatibility molecule.  Nature Immunology, 8, 268-276.

Ueno, A., Ansari, A., Coppel, R.L., Mackay, I.R., and Gershwin, M.E.  (2007) AMA production in primary biliary cirrhosis is promoted by the TLR9 ligand CpG and suppressed by potassium channel blockers.  Hepatology, 45, 314-322.

Walter, M., Lucet, I.S., Patel, O., Broughton, S.E., Bamert, R., Williams, N.K., Fantino, E., Wilks, A.F., and Rossjohn, J.  (2007) The 2.7 Å crystal structure of the autoinhibited human c-Fms kinase domain.  Journal of Molecular Biology, 367, 839-847.

Waller, K.L., Stubberfield, L.M., Dubljevic, V., Nunomura, W., An, X., Mason, A.J., Mohandas, N., Cooke, B.M., and Coppel, R.L.  (2007) Interactions of Plasmodium falciparum erythrocyte membrane protein 3 with the red blood cell membrane skeleton.  Biochimica et Biophysica Acta, 1768, 2145-2156.

Wang, S.X., Pandey, K.C., Scharfstein, J., Whisstock, J.C., Huang, R.K., Jacobelli,  J., Fletterick, R.J., Rosenthal, P.J., Abrahamson, M., Brinen, L.S., Rossi, A., Sali, A., and McKerrow, J.H.  (2007)  The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family.  Structure, 15, 535-543.

Wiradjaja, F., Ooms, L.M., Tahirovic, S., Kuhne, E., Devenish, R.J., Munn, A.L., Piper, R.C., Mayinger, P., and Mitchell, C.A.  (2007)  Phosphatidylinositol 4, 5-bisphosphate accumulates on vacuole membranes following inactivation of the phosphoinositide phosphatase Sac1p and the inositol polyphosphate 5-phosphatase Inp54p.  Journal of Biological Chemistry, 282, 16295-16307.

Young, G., Turner, S., Davies, J.K., Sundqvist, G., and Figdor, D.  (2007)  Bacterial DNA persists for extended periods after cell death.  Journal of Endodontics, 33, 1417-1420.